Preferred Label : Cabazitaxel;
NCIt synonyms : 1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl
4-acetate 2-benzoate 13-[(2R,3S)-3-{[(tertbutoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoate]; Taxoid XRP6258;
NCIt related terms : Jevtana;
NCIt definition : A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential
antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in
the inhibition of microtubule depolymerization and cell division, cell cycle arrest
in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane
compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance
(MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant
tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).;
Alternative definition : NCI-GLOSS: A drug used with prednisone to treat hormone-resistant prostate cancer
that has spread and that had been treated with docetaxel. It is also being studied
in the treatment of other types of cancer. Cabazitaxel blocks cell growth by stopping
cell division and may kill cancer cells. It is a type of antimitotic agent.;
UNII : 51F690397J;
InChIKey : BMQGVNUXMIRLCK-OAGWZNDDSA-N;
CAS number : 183133-96-2;
Drug name : Jevtana;
Molecule name : RPR-116258A; XRP-6258; TXD 258; RPR 116258A; TXD-258; XRP 6258;
Chemical formula : C45H57NO14;
ChEBI ID : CHEBI:63584;
Codes from synonyms : CDR0000682154; CDR0000682155; CDR0000682153; 81;
Origin ID : C66937;
UMLS CUI : C2830183;
Automatic exact mappings (from CISMeF team)
- XRP6258 [MeSH Supplementary Concept]
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
