Valopicitabine

Preferred Label : Valopicitabine;

NCIt definition : The 3-O-valine ester prodrug of the nucleoside analog 2'-C-methylcytidine with anti-hepatitis C virus (HCV) activity. Upon administration, valopicitabine is converted into 2'-C-methylcytidine; upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication.;

UNII : I2T0B5G94M;

InChIKey : TVRCRTJYMVTEFS-ICGCPXGVSA-N;

CAS number : 640281-90-9;

Chemical formula : C15H24N4O6;

Details

Origin ID

C66649;

UMLS CUI

C1664150;

Currated CISMeF NLP mapping
- valopicitabine [MeSH concept]
- valopicitabine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- valopicitabine [MeSH Supplementary Concept]
- valopicitabine [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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