NCIt definition : The hydrochloride salt form of propiomazine, a phenothiazine derivative and atypical
antipsychotic agent with sedative, antiemetic and antipsychotic activities. Propiomazine
binds to a variety of receptors, including alpha1, dopamine, histamine H1, muscarinic,
and serotonin type 2 (5-HT2) receptors. Propiomazine exerts its antiemetic and sedative
effects through antagonism at histamine H1 receptors; Its antipsychotic effect is
attributed to antagonistic activities at dopamine and 5-HT2 receptors.;