NCIt definition : A phenothiazine derivative and atypical antipsychotic agent with sedative, antiemetic
and antipsychotic activities. Propiomazine binds to a variety of receptors, including
alpha1, dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
Propiomazine exerts its antiemetic and sedative effects through antagonism at histamine
H1 receptors; Its antipsychotic effect is attributed to antagonistic activities at
dopamine and 5-HT2 receptors.;