Preferred Label : Pradefovir Mesylate;
NCIt synonyms : Remofovir Mesylate; 9-(2-(4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl)methoxyethyl)adenine; 9H-Purin-6-amine, 9-(2-(((2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-methoxy)ethyl)-,
Monomethanesulfonate;
NCIt definition : The mesylate salt form of pradefovir, a cyclodiester antiviral prodrug with specific
activity against hepatitis B virus (HBV). Pradefovir is specifically metabolized in
the liver by hepatic enzymes, mainly by CYP4503A4, to adefovir. In turn, adefovir
is phosphorylated by cellular kinases to its activated form adevofir diphosphate.
By competing with the natural substrate dATP, the diphosphate form is incorporated
into viral DNA and inhibits RNA-dependent DNA polymerase. This causes DNA chain termination
and eventually results in an inhibition of HBV replication.;
UNII : 0D5204ZSIX;
InChIKey : JXQUAHHUSMJUFV-HZPZRMRQSA-N;
CAS number : 625095-61-6;
Drug name : Hepavir B;
Molecule name : MB-06866Q;
Chemical formula : C17H19ClN5O4P.CH4O3S;
Origin ID : C66454;
UMLS CUI : C1566740;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
