Pradefovir - CISMeF

Preferred Label : Pradefovir;

NCIt synonyms : Remofovir;

NCIt definition : A cyclodiester antiviral prodrug with specific activity against hepatitis B virus (HBV). Pradefovir is specifically metabolized in the liver by hepatic enzymes, mainly by CYP4503A4, to adefovir. In turn, adefovir is phosphorylated by cellular kinases to its activated form adevofir diphosphate. By competing with the natural substrate dATP, the diphosphate form is incorporated into viral DNA and inhibits RNA-dependent DNA polymerase. This causes DNA chain termination and eventually results in an inhibition of HBV replication.;

UNII : GZE85Q9Q61;

InChIKey : GWNHAOBXDGOXRR-HJFSHJIFSA-N;

CAS number : 625095-60-5;

Chemical formula : C17H19ClN5O4P;

Details

Origin ID

C66453;

UMLS CUI

C1692892;

Currated CISMeF NLP mapping
- pradefovir [MeSH concept]
- pradefovir [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- pradefovir [MeSH concept]
- pradefovir [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Pradefovir Mesylate [NCIt concept]
is_free_acid_or_base_form_of
- Pradefovir Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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