Preferred Label : Mitotane;
NCIt synonyms : Mytotan; 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; DDD; 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane; o,p'-DDD; Ortho,para-DDD; 2,4'-Dichlorodiphenyldichloroethane; 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane; o,p' - DDD; Khloditan;
NCIt related terms : CB 313; 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; Chloditan; 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane; Lysodren; Chlodithane; Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-; 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; 2, 4'-Dichlorodiphenyldichloroethane; (o,p)-DDD;
NCIt definition : A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with
anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to
a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins,
specifically inhibiting adrenal cortical hormone production. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug used in treating adrenocortical cancer and ACTH-producing
pituitary tumors (Cushing's disease).;
UNII : 78E4J5IB5J;
InChIKey : JWBOIMRXGHLCPP-UHFFFAOYSA-N;
CAS number : 53-19-0;
Drug name : Lisodren; Lysodren;
Molecule name : CB-313; WR-13045;
Chemical formula : C14H10Cl4;
NSC code : 38721;
Codes from synonyms : 07096; NSC0038721; CDR0000045227; 335;
Origin ID : C664;
UMLS CUI : C0026256;
Automatic exact mappings (from CISMeF team)
False automatic mappings
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
concept_is_in_subset
is_component_of_chemotherapy_regimen