Mitotane - CISMeF

Preferred Label : Mitotane;

NCIt synonyms : Mytotan; 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; DDD; 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane; o,p'-DDD; Ortho,para-DDD; 2,4'-Dichlorodiphenyldichloroethane; 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane; o,p' - DDD; Khloditan;

NCIt related terms : CB 313; 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; Chloditan; 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane; Lysodren; Chlodithane; Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-; 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; 2, 4'-Dichlorodiphenyldichloroethane; (o,p)-DDD;

NCIt definition : A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease).;

UNII : 78E4J5IB5J;

InChIKey : JWBOIMRXGHLCPP-UHFFFAOYSA-N;

CAS number : 53-19-0;

Drug name : Lisodren; Lysodren;

Molecule name : CB-313; WR-13045;

Chemical formula : C14H10Cl4;

NSC code : 38721;

Codes from synonyms : 07096; NSC0038721; CDR0000045227; 335;

Details

Origin ID

C664;

UMLS CUI

C0026256;

Automatic exact mappings (from CISMeF team)
- Oculodentodigital dysplasia [OMIM Phenotype]
- dichlorodiphenyldichloroethane [MeSH concept]
- dichlorodiphenyldichloroethane [MeSH Descriptor]
- dichlorodiphenyldichloroethane [Substance BNPC]
- gap junction protein alpha 1 [ORDO Gene]
- o,p'- DDD [LOINC component]
- olean-11,13(18)-diene-3,30-diol dihemiphthalate, disodium salt [MeSH Supplementary Concept]
False automatic mappings
- Dowling-degos disease 1 [OMIM Phenotype]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Mitotane [ICD-11 Extension code]
- Mitotane [LOINC component]
- Mitotane (substance) [SNOMED CT concept]
- Product containing mitotane (medicinal product) [SNOMED CT concept]
- mitotane [ATC Code]
- mitotane [Substance BNPC]
- mitotane [MeSH concept]
- mitotane [MeSH Descriptor]
- mitotane [SNOMED Notion]
- o,p'- DDD [LOINC component]
Validated automatic mappings to BTNT
- mitotane [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Mitotane [NCIt concept]
- Doxorubicin/Etoposide/Mitotane/Tariquidar/Vincristine [NCIt concept]
- Doxorubicin/Etoposide/Mitotane/Vincristine [NCIt concept]
- EDP-M Regimen [NCIt concept]
- Mitotane Regimen [NCIt concept]
- Mitotane/Pembrolizumab Regimen [NCIt concept]
- Mitotane/Streptozocin Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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