Penciclovir - CISMeF

Preferred Label : Penciclovir;

NCIt synonyms : 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-; 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine;

NCIt definition : A synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.;

UNII : 359HUE8FJC;

InChIKey : JNTOCHDNEULJHD-UHFFFAOYSA-N;

CAS number : 39809-25-1;

Drug name : Denavir;

Molecule name : BRL 39123; BRL-39123; CCRIS 9213;

Chemical formula : C10H15N5O3;

ChEBI ID : CHEBI:7956;

Details

Origin ID

C66337;

UMLS CUI

C0164815;

Currated CISMeF NLP mapping
- Penciclovir [LOINC component]
- Penciclovir (substance) [SNOMED CT concept]
- penciclovir [MeSH concept]
- penciclovir [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Penciclovir [LOINC component]
- Penciclovir (substance) [SNOMED CT concept]
- Product containing penciclovir (medicinal product) [SNOMED CT concept]
- penciclovir [ATC Code]
- penciclovir [ATC Code]
- penciclovir [MeSH concept]
- penciclovir [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- penciclovir [ATC Code]
- penciclovir [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Penciclovir Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Penciclovir Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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