Penciclovir Sodium

Preferred Label : Penciclovir Sodium;

NCIt synonyms : 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine, Monosodium Salt; 1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one Monosodium Salt;

NCIt definition : The sodium salt form of penciclovir, a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.;

UNII : P06226385L;

InChIKey : NMQFQBOIHUIALG-UHFFFAOYSA-M;

CAS number : 97845-62-0;

Chemical formula : C10H14N5O3.Na;

Details

Origin ID

C47656;

UMLS CUI

C0892839;

Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- penciclovir, monosodium salt [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Penciclovir [NCIt concept]
is_salt_form_of
- Penciclovir [NCIt concept]

Keyword's position in hierarchy(ies) :

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