Pargyline Hydrochloride

Preferred Label : Pargyline Hydrochloride;

NCIt definition : The hydrochloride salt form of pargyline, a monoamine oxidase (MAO) inhibitor with antidepressant activity. Pargyline selectively inhibits MAO type B, an enzyme catalyzing the oxidative deamination and inactivation of certain catecholamines, such as norepinephrine and dopamine, within the presynaptic nerve terminals. By inhibiting the metabolism of these biogenic amines in the brain, pargyline increases their concentration and binding to postsynaptic receptors. Increased receptor stimulation may cause downregulation of central receptors which may attribute to pargyline's antidepressant effect.;

UNII : W70V6I2OMY;

InChIKey : BCXCABRDBBWWGY-UHFFFAOYSA-N;

CAS number : 306-07-0;

Chemical formula : C11H13N.HCl;

NSC code : 43798;

Details

Origin ID

C66323;

UMLS CUI

C0282289;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pargyline hydrochloride [Substance BNPC]
- Pargyline hydrochloride (substance) [SNOMED CT concept]
- pargyline hydrochloride [SNOMED Notion]
- pargyline hydrochloride [MeSH concept]
Validated automatic mappings to NTBT
- pargyline [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Pargyline [NCIt concept]
is_salt_form_of
- Pargyline [NCIt concept]

Keyword's position in hierarchy(ies) :

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