Pargyline - CISMeF

Preferred Label : Pargyline;

NCIt synonyms : N-Methyl-N-2-Propynylbenzylamine;

NCIt definition : A monoamine oxidase (MAO) inhibitor with antidepressant activity. Pargyline selectively inhibits MAO type B, an enzyme catalyzing the oxidative deamination and inactivation of certain catecholamines, such as norepinephrine and dopamine, within the presynaptic nerve terminals. By inhibiting the metabolism of these biogenic amines in the brain, pargyline increases their concentration and binding to postsynaptic receptors. Increased receptor stimulation may cause downregulation of central receptors which may attribute to pargyline's antidepressant effect.;

UNII : 9MV14S8G3E;

InChIKey : DPWPWRLQFGFJFI-UHFFFAOYSA-N;

CAS number : 555-57-7;

Chemical formula : C11H13N;

Details

Origin ID

C66322;

UMLS CUI

C0030557;

Automatic exact mappings (from CISMeF team)
- Pargyline [ICHI extension code]
Currated CISMeF NLP mapping
- Pargyline [LOINC component]
- Pargyline [ICD-11 Extension code]
- Pargyline (substance) [SNOMED CT concept]
- pargyline [Substance BNPC]
- pargyline [MeSH Descriptor]
- pargyline [MeSH concept]
- pargyline [SNOMED Notion]
See also inter- (CISMeF)
- Product containing pargyline (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pargyline [LOINC component]
- Pargyline [ICD-11 Extension code]
- Pargyline (substance) [SNOMED CT concept]
- Product containing pargyline (medicinal product) [SNOMED CT concept]
- pargyline [ATC Code]
- pargyline [Substance BNPC]
- pargyline [SNOMED Notion]
- pargyline [MeSH Descriptor]
- pargyline [MeSH concept]
Validated automatic mappings to BTNT
- pargyline [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Pargyline Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Pargyline Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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