NCIt definition : The hydrochloride salt form of parconazole, a broad spectrum imidazole derivative
with antifungal activity. Although the exact mechanism of action has yet to be fully
elucidated, parconazole, like other azole antifungals, most likely inhibits the cytochrome
P450 dependent 14 alpha demethylation of lanosterol. This prevents the synthesis of
ergosterol which is a crucial component of the fungal cell membrane. By disrupting
fungal cell membrane synthesis and integrity, parconazole alters fungal cell membrane
permeability, promotes loss of essential intracellular components and eventually inhibits
fungal cell growth.;
Semantic type(s)