NCIt definition : A broad spectrum imidazole derivative with antifungal activity. Although the exact
mechanism of action has yet to be fully elucidated, parconazole, like other azole
antifungals, most likely inhibits the cytochrome P450 dependent 14 alpha demethylation
of lanosterol. This prevents the synthesis of ergosterol which is a crucial component
of the fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity,
parconazole alters fungal cell membrane permeability, promotes loss of essential intracellular
components and eventually inhibits fungal cell growth.;
Semantic type(s)