NCIt definition : The hydrochloride salt form of oxprenolol, a lipophilic, nonselective beta-adrenergic
receptor antagonist with anti-arrhythmic, anti-anginal and antihypertensive activities.
Oxprenolol competitively binds to and blocks beta-1 adrenergic receptors in the heart,
thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac
output and lowers blood pressure. In addition, oxprenolol prevents the release of
renin, a hormone secreted by the kidneys that causes constriction of blood vessels.;