Netilmicin - CISMeF

Preferred Label : Netilmicin;

NCIt definition : A semisynthetic, water soluble aminoglycoside derived from sisomicin, a naturally occurring antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.;

UNII : 4O5J85GJJB;

InChIKey : CIDUJQMULVCIBT-MQDUPKMGSA-N;

CAS number : 56391-56-1;

Chemical formula : C21H41N5O7;

ChEBI ID : CHEBI:7528;

Details

Origin ID

C66236;

UMLS CUI

C0027780;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Netilmicin [ICD-11 Extension code]
- Netilmicin [LOINC component]
- Netilmicin (substance) [SNOMED CT concept]
- Product containing netilmicin (medicinal product) [SNOMED CT concept]
- netilmicin [ATC Code]
- netilmicin [ATC Code]
- netilmicin [Substance BNPC]
- netilmicin [SNOMED Notion]
- netilmicin [MeSH Descriptor]
- netilmicin [MeSH concept]
Validated automatic mappings to BTNT
- netilmicin [ATC Code]
- netilmicin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Netilmicin Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Netilmicin Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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