NCIt definition : The fumarate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic
receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic
activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby
reducing the rate and force of myocardial contraction, and consequently a diminished
cardiac output. This agent may also reduce the secretion of renin with subsequent
reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone
secretion.;
Semantic type(s)