Preferred Label : Ivabradine;
NCIt synonyms : (S)-3-(3-(((3,4-Dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one; 2H-3-Benzazepin-2-one, 3-(3-(((3,4-Dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-,
(S)-;
NCIt definition : An orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN)
channel blocker, with negative chronotropic activity. Upon administration, ivabradine
selectively binds to the intracellular portion of the HCN channel pore and blocks
HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits
the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation
of positively charged ions, reduces pacemaker activity and slows diastolic depolarization.
This decreases heart rate, reduces myocardial oxygen demand and allows more time for
blood to flow to the myocardium without affecting cardiac contractility. HCN channels,
mixed sodium (Na ) and potassium (K ) channels that carry the inward If current, play
a key role in the regulation of pacemaker firing rate in the SA node. The If pacemaker
current, the inward flow of positively charged Na -K ions, initiates the spontaneous
diastolic depolarization phase and modulating heart rate.;
UNII : 3H48L0LPZQ;
InChIKey : ACRHBAYQBXXRTO-OAQYLSRUSA-N;
CAS number : 155974-00-8;
Molecule name : S-16257; S 16257;
Chemical formula : C27H36N2O5;
Origin ID : C65995;
UMLS CUI : C0257190;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
