" /> Plicamycin - CISMeF





Preferred Label : Plicamycin;

NCIt synonyms : MTH; Mithramycin; Aureolic acid;

NCIt related terms : PA-144; A-2371; Mithracin;

NCIt definition : An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.;

UNII : NIJ123W41V;

InChIKey : CFCUWKMKBJTWLW-BKHRDMLASA-N;

CAS number : 18378-89-7;

Drug name : Mithracin; Mithracine;

Molecule name : PA-144; A-2371;

Chemical formula : C52H76O24;

NSC code : 24559;

ChEBI ID : CHEBI:31856;

Codes from synonyms : NSC0024559; CDR0000484118; CDR0000463729; CDR0000476348; 408;

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08/05/2025


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