Plicamycin - CISMeF

Preferred Label : Plicamycin;

NCIt synonyms : MTH; Mithramycin; Aureolic acid;

NCIt related terms : PA-144; A-2371; Mithracin;

NCIt definition : An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.;

UNII : NIJ123W41V;

InChIKey : CFCUWKMKBJTWLW-BKHRDMLASA-N;

CAS number : 18378-89-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 18378-89-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Mithracin; Mithracine;

Molecule name : PA-144; A-2371;

Chemical formula : C52H76O24;

NSC code : 24559;

ChEBI ID : CHEBI:31856;

Codes from synonyms : NSC0024559; CDR0000484118; CDR0000463729; CDR0000476348; 408;

Details

Origin ID

C658;

UMLS CUI

C0026234;

Automatic exact mappings (from CISMeF team)
- Mithramycin [ICHI extension code]
- Plicamycin [ICHI extension code]
- metathalamus [UBERON concept]
- mithramycin A [MeSH Supplementary Concept]
- mithramycin A [MeSH concept]
See also inter- (CISMeF)
- Product containing plicamycin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Mithramycin [ICD-11 Extension code]
- Plicamycin [ICD-11 Extension code]
- Plicamycin (substance) [SNOMED CT concept]
- Product containing plicamycin (medicinal product) [SNOMED CT concept]
- plicamycin [ATC Code]
- plicamycin [MeSH concept]
- plicamycin [MeSH Descriptor]
- plicamycin [SNOMED Notion]
Validated automatic mappings to BTNT
- plicamycin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA [NCIt concept]

Keyword's position in hierarchy(ies) :

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