Fosinopril - CISMeF

Preferred Label : Fosinopril;

NCIt definition : A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow.;

UNII : R43D2573WO;

InChIKey : BIDNLKIUORFRQP-FLODCBCLSA-N;

CAS number : 98048-97-6;

Chemical formula : C30H46NO7P;

ChEBI ID : CHEBI:5163;

Details

Origin ID

C65761;

UMLS CUI

C0118168;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Fosinopril [ICD-11 Extension code]
- Fosinopril [LOINC component]
- Fosinopril (substance) [SNOMED CT concept]
- Product containing fosinopril (medicinal product) [SNOMED CT concept]
- fosinopril [ATC Code]
- fosinopril [MeSH concept]
- fosinopril [MeSH Descriptor]
Validated automatic mappings to BTNT
- fosinopril [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Fosinopril Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Fosinopril Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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