" /> Fosinopril Sodium - CISMeF





Preferred Label : Fosinopril Sodium;

NCIt synonyms : Eliten; L-proline, 4-Cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy) propoxyl](4-phenylbutyl) phosphinyl]acetyl]-,Sodium Salt, trans-;

NCIt definition : The sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium. (NCI05);

UNII : NW2RTH6T2N;

InChIKey : TVTJZMHAIQQZTL-LVCDZQEYSA-M;

CAS number : 88889-14-9;

Drug name : Newace; Monopril;

Chemical formula : C30H45NO7P.Na;

ChEBI ID : CHEBI:5164;

Codes from synonyms : 32057;

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08/05/2025


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