" /> Forodesine - CISMeF





Preferred Label : Forodesine;

NCIt definition : A transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), with potential antineoplastic activity. Upon administration, forodesine preferentially binds to and inhibits PNP, resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of leukemia and lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor.;

UNII : 426X066ELK;

InChIKey : IWKXDMQDITUYRK-KUBHLMPHSA-N;

CAS number : 209799-67-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 209799-67-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C11H14N4O4;

ChEBI ID : CHEBI:43362;

Codes from synonyms : CDR0000413946; 232;

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23/05/2024


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