NCIt definition : The hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine.
Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP),
resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition
of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively
causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue
is a substrate designed to mimic the properties or the geometry of the transition
state of reaction.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of leukemia and
lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor.;
UNII : 6SN82Y9U73;
InChIKey : WEIAMZKHBCLFOG-QPAIBFMUSA-N;
CAS number : 284490-13-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 284490-13-7
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G-SRS /a ;
Drug name : Fodosine; Mundesine;
Molecule name : BCX-1777;
Chemical formula : C11H14N4O4.HCl;
Codes from synonyms : CDR0000512981; CDR0000306505;