NCIt definition : A long-acting beta-adrenergic receptor agonist with bronchodilator activity. Formoterol
selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby
activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of
adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased
cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve
mucociliary clearance and reduce mediator substance release from inflammatory cells,
especially from mast cells.;