Misonidazole - CISMeF

Preferred Label : Misonidazole;

NCIt synonyms : 1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole;

NCIt related terms : RO 7-0582;

NCIt definition : A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis. (NCI04);

UNII : 8FE7LTN8XE;

InChIKey : OBBCSXFCDPPXOL-UHFFFAOYSA-N;

CAS number : 13551-87-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 13551-87-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : Ro-07-0582; Ro-7-0582;

Chemical formula : C7H11N3O4;

NSC code : 261037;

Codes from synonyms : NSC0261037;

Details

Origin ID

C657;

UMLS CUI

C0026218;

Automatic exact mappings (from CISMeF team)
- Misonidazole [ICHI extension code]
Currated CISMeF NLP mapping
- Misonidazole [ICD-11 Extension code]
- Misonidazole (substance) [SNOMED CT concept]
- misonidazole [Substance BNPC]
- misonidazole [MeSH Descriptor]
- misonidazole [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Misonidazole [ICD-11 Extension code]
- Misonidazole (substance) [SNOMED CT concept]
- misonidazole [Substance BNPC]
- misonidazole [MeSH concept]
- misonidazole [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Altretamine/Cisplatin/Cyclophosphamide/Misonidazole [NCIt concept]
- Carmustine/Cyclophosphamide/Melphalan/Misonidazole/Prednisone [NCIt concept]
- Cisplatin/Cyclophosphamide/Doxorubicin/Misonidazole [NCIt concept]
- Melphalan/Misonidazole [NCIt concept]

Keyword's position in hierarchy(ies) :

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