NCIt definition : The olamine salt form of ciclopirox, a synthetic, broad-spectrum antifungal agent
with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts
its action by binding to and chelating trivalent cations, such as Fe3 and Al3 , thereby
inhibiting the availability of essential co-factors for enzymes. This may lead to
a loss of activity of enzymes that are essential for cellular metabolism, organization
of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts
its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).;