NCIt definition : The hydrochloride salt of bacampicillin, a prodrug of ampicillin, a broad-spectrum,
semisynthetic, beta-lactam aminopenicillin antibiotic with bactericidal activity.
Bacampicillin is hydrolyzed in vivo by esterases to its active metabolite ampicillin.
Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the
inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the
cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and
rigidity. This interrupts bacterial cell wall synthesis and results in the weakening
of the bacterial cell wall and causes cell lysis.;