NCIt definition : The hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative
with antimalarial and anti-inflammatory properties. Similar in structure and activity
to chloroquine, amodiaquine is effective against some chloroquine-resistant strains,
particularly Plasmodium falciparum, the most deadly malaria parasite. Although the
mechanism of plasmodicidal action has not been fully elucidated, like other quinoline
derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the
body. This results in accumulation of free heme, which is toxic to the parasites.;
Semantic type(s)