Amodiaquine - CISMeF

Preferred Label : Amodiaquine;

NCIt definition : An orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.;

UNII : 220236ED28;

InChIKey : OVCDSSHSILBFBN-UHFFFAOYSA-N;

CAS number : 86-42-0;

Chemical formula : C20H22ClN3O;

ChEBI ID : CHEBI:2674;

Details

Origin ID

C65231;

UMLS CUI

C0002641;

Currated CISMeF NLP mapping
- Amodiaquine [ICD-11 Extension code]
- Amodiaquine (substance) [SNOMED CT concept]
- Product containing amodiaquine (medicinal product) [SNOMED CT concept]
- amodiaquin [SNOMED Notion]
- amodiaquine [Substance BNPC]
- amodiaquine [MeSH Descriptor]
- amodiaquine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Amodiaquine [ICD-11 Extension code]
- Amodiaquine (substance) [SNOMED CT concept]
- Product containing amodiaquine (medicinal product) [SNOMED CT concept]
- amodiaquin [SNOMED Notion]
- amodiaquine [ATC Code]
- amodiaquine [Substance BNPC]
- amodiaquine [MeSH concept]
- amodiaquine [MeSH Descriptor]
Validated automatic mappings to BTNT
- amodiaquine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Amodiaquine Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Amodiaquine Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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