NCIt definition : The hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with
bactericidal activity against most organisms and bacteriostatic effect on enterococci.
At a site different from that of penicillins and cephalosporins, vancomycin binds
tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering
with bacterial cell wall synthesis. This leads to activation of bacterial autolysins
that destroy the cell wall by lysis. Vancomycin may also alter the permeability of
bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis.;