Liposomal Oxaliplatin

Preferred Label : Liposomal Oxaliplatin;

NCIt definition : The liposomal preparation of oxaliplatin, an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group'. A leaving group is an atom or a group of atoms that is displaced as a stable species taking with it its bonding electrons. After displacement of the labile oxalate ligand leaving group, the active oxaliplatin derivatives (monoaquo and diaquo DACH platinum) alkylate macromolecules, and form both inter- and intra-strand platinum-DNA crosslinks, thereby inhibiting DNA replication and resulting in cytotoxicity. The DACH side chain appears to inhibit DNA repair mechanism, therefore overcoming the limits observed in other platinum-based therapies.;

Drug name : Lipoxal;

Details

Origin ID

C65110;

UMLS CUI

C1831940;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- DNA Crosslinking [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- DNA Synthesis Inhibition [NCIt concept]
- RNA Transcription Inhibition [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- DNA [NCIt concept]

Keyword's position in hierarchy(ies) :

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