NCIt definition : A low molecular weight polymer-conjugated platinum complex with potential antineoplastic
activity. This polymer drug delivery system consists of cytotoxic diaminocyclohexane
(DACH)-platinum (Pt) coupled to a water-soluble biocompatible hydroxypropylmethacrylamide
(HPMA) copolymer via a pH sensitive linker. Due to decreased pH at the tumor site,
the linker is cleaved and the chelated active moiety DACH-Pt is released in tumor
cells. DACH-Pt alkylates macromolecules and causes both inter- and intra-strand platinum-DNA
crosslinks, which impede DNA replication and transcription, thereby resulting in cell-cycle
independent cytotoxicity. The HPMA-based drug delivery system enhances the concentration
of DACH-Pt at the tumor site and prolongs the half life of the agent, thereby increasing
exposure and efficacy at the target tumor sites while minimizing side effects in normal
tissues.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of head and neck cancer. It
may kill cancer cells by carrying an anticancer drug into the tumor. It is a type
of platinum compound.;