" /> Navitoclax - CISMeF





Preferred Label : Navitoclax;

NCIt synonyms : BcI-2 Family Protein Inhibitor ABT-263;

NCIt related terms : ABT-263;

NCIt definition : An orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Navitoclax selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w, which are frequently overexpressed in a wide variety of cancers, including those of the lymph, breast, lung, prostate, and colon, and are linked to tumor drug resistance. Inhibition of these apoptosis suppressors prevents their binding to the apoptotic effectors Bax and Bak proteins, thereby triggering apoptotic processes in cells overexpressing Bcl-2, Bcl-XL, and Bcl-w. This eventually reduces tumor cell proliferation.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of lymphomas and other types of cancer. It blocks some of the enzymes that keep cancer cells from dying. It is a type of Bcl-2 family inhibitor.;

UNII : XKJ5VVK2WD;

InChIKey : JLYAXFNOILIKPP-KXQOOQHDSA-N;

CAS number : 923564-51-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 923564-51-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ABT-263; A-855071.0;

Chemical formula : C47H55ClF3N5O6S3;

Codes from synonyms : CDR0000533413; CDR0000674058;

Details


You can consult :


Nous contacter.
09/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.