" /> Tagraxofusp-erzs - CISMeF





Preferred Label : Tagraxofusp-erzs;

NCIt synonyms : Diphtheria Toxin(388)-Interleukin-3 Fusion Protein; DT(388)-IL3 Fusion Protein; IL3R-targeting Fusion Protein SL-401; Diphtheria Toxin 388 Interleukin-3 Fusion Protein; S)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol; Tagraxofusp ERZS;

NCIt related terms : DT388IL3 fusion protein; TAGRAXOFUSP;

NCIt definition : A recombinant protein consisting of human interleukin 3 (IL3) fused to the first 388 amino acids of diphtheria toxin [DT(388)] (DT388IL3) with potential antineoplastic activity. Upon intravenous administration of tagraxofusp-erzs, the IL3 moiety binds to IL3 receptors on cells expressing the receptor. Subsequently, the DT(388) toxin moiety, which contains both translocation and catalytic domains, is transported across the cell membrane via endocytosis. Within the cytosol, the catalytic domain of the toxin both catalyzes the ADP-ribosylation of, and inactivates, translation elongation factor 2 (EF-2), which results in the inhibition of translation during protein synthesis. IL3 may be overexpressed by a variety of cancers, including blastic plasmacytoid dendritic cell neoplasm and acute myeloid leukemia (AML).;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of myeloid leukemia (a disease in which too many immature non-lymphocyte white blood cells are found in the blood and bone marrow). DT388IL3 fusion protein is made by combining IL-3 with a toxic substance. The IL-3 attaches to the cancer cells and the toxic substance kills them.;

UNII : 8ZHS5657EH;

CAS number : 2055491-00-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2055491-00-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Elzonris;

Molecule name : SL-401;

Codes from synonyms : CDR0000530324; 475;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
15/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.