E2F1 Pathway Activator ARQ 171

Preferred Label : E2F1 Pathway Activator ARQ 171;

NCIt synonyms : ARQ 171;

NCIt definition : A second-generation E2F1 pathway activator with potential antineoplastic activity. ARQ 171 induces the expression of E2F transcription factor 1, thereby activating the E2F1-mediated checkpoint process. E2F1, down-regulated in cancer cells, regulates expression of genes involved in the cell cycle progression from G1 into S phase. The G1/S checkpoint process selectively induces cell cycle arrest in cancer cells with irreparable DNA damages and triggers subsequent apoptosis, while allowing cell division to proceed in cells without or with minor reparable DNA damage. As a result, this agent exerts anti-tumor activity through checkpoint activation independent of p53 mediated tumor suppression.;

Molecule name : ARQ 171;

Détails

Origin ID

C64767;

UMLS CUI

C1832018;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Transcription Factor E2F1 [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Cell Cycle [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Transcription Factor E2F1 [NCIt concept]

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