Preferred Label : Sinomenine;
NCIt synonyms : Cucoline; Sabianine A; Coculine; 4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en-6-one;
NCIt definition : An alkaloid isolated from the root of Sinomenium acutum with immunomodulatory and
potential anti-angiogenic and activities. Although the mechanism of action remains
to be fully elucidated, sinomenine appears to inhibit endothelial proliferation mediated
through basic fibroblast growth factor (bFGF), which may contribute to its anti-angiogenic
effect. In Chinese medicine, this agent has a long track-record in treating arthritis,
which is accounted by its ability to inhibit proliferation of synovial fibroblasts
and lymphocytes. In addition, sinomenine has been shown to suppress expressions of
genes involved in inflammation and apoptosis, such as interleukin-6, a pleiotropic
inflammatory cytokine and JAK3 (Janus kinase 3), Daxx (death-associated protein 6),
plus HSP27 (heat shock 27kDa protein 1), respectively.;
UNII : 63LT81K70N;
CAS number : 115-53-7;
PubMed : 16566946;
Origin ID : C64766;
UMLS CUI : C0074568;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
