picrotoxin - CISMeF

Preferred Label : picrotoxin;

MeSH definition : A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.; A mixture of PICROTOXININ and PICROTIN that is a noncompetitive antagonist at GABA-A receptors acting as a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.;

MeSH synonym : 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8; Cocculin;

MeSH CAS label : 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione (1:1);

MeSH Related Number : 124-87-8;

Registry Number MeSH : 124-87-8;

Codes EINECS : 204-716-6;

Is substance : O;

UNII : ZLT174DL7U;

Details

Origin ID

D010852;

UMLS CUI

C0031890;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- picrotoxin [Substance BNPC]
Currated CISMeF NLP mapping
- Picrotoxin [ICD-11 Extension code]
- Picrotoxin (substance) [SNOMED CT concept]
- picrotoxin [SNOMED Notion]
Pharmacological action(s)
- GABA-A receptor antagonists [MeSH Descriptor]
- antidotes [MeSH Descriptor]
- convulsants [MeSH Descriptor]
Record concept(s)
- picrotoxin [MeSH concept]
Related MeSH Supplementary Concept(s)
- coriamyrtine [MeSH Supplementary Concept]
- dihydropicrotoxinin [MeSH Supplementary Concept]
- hyenanchin [MeSH Supplementary Concept]
- picrotin [MeSH Supplementary Concept]
- picrotoxinin [MeSH Supplementary Concept]
- tutin [MeSH Supplementary Concept]
- vertigoheel [MeSH Supplementary Concept]
Semantic type(s)
- Hazardous or Poisonous Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Picrotoxin [ICD-11 Extension code]
- Picrotoxin (substance) [SNOMED CT concept]
- picrotoxin [Substance BNPC]
- picrotoxin [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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