" /> Efatutazone Dihydrochloride - CISMeF





Preferred Label : Efatutazone Dihydrochloride;

NCIt synonyms : Inolitazone Dihydrochloride; 2,4-thiazolidinedione, 5-((4-((6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1h-benzimidazol-2-yl)methoxy)phenyl)methyl)-, Hydrochloride (1:2);

NCIt definition : The dihydrochloride salt of efatutazone, an orally bioavailable agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma, a nuclear hormone receptor and a ligand-activated transcription factor controling gene expression involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation. Mediated through activation of PPAR-gamma, this agent is capable of inducing cell differentiation and apoptosis, thereby leading to a reduction in cellular proliferation.;

UNII : 76B44WEA8O;

InChIKey : WFIOHOJEIMQCEG-UHFFFAOYSA-N;

CAS number : 223132-38-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 223132-38-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CS-7017;

Chemical formula : C27H26N4O4S.2ClH;

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15/05/2024


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