NCIt definition : The dihydrochloride salt of efatutazone, an orally bioavailable agonist of peroxisome
proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity.
Efatutazone binds to and activates PPAR-gamma, a nuclear hormone receptor and a ligand-activated
transcription factor controling gene expression involved in macromolecule metabolism
and cell differentiation, specifically adipocyte differentiation. Mediated through
activation of PPAR-gamma, this agent is capable of inducing cell differentiation and
apoptosis, thereby leading to a reduction in cellular proliferation.;