Pregabalin - CISMeF

Preferred Label : Pregabalin;

NCIt synonyms : 3-Isobutyl GABA; 3-(Aminomethyl)-5-methyl-hexanoic Acid;

NCIt related terms : Lyrica;

NCIt definition : A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.;

Alternative definition : NCI-GLOSS: A drug used to treat nerve pain caused by diabetes or herpes zoster infection and certain types of seizures. It is being studied in the prevention and treatment of nerve pain in the hands and feet of cancer patients given chemotherapy. Pregabalin is a type of anticonvulsant.;

UNII : 55JG375S6M;

InChIKey : AYXYPKUFHZROOJ-ZETCQYMHSA-N;

CAS number : 148553-50-8;

Drug name : Lyrica;

Molecule name : CI 1008; PD 144723;

Chemical formula : C8H17NO2;

NSC code : 759256;

ChEBI ID : CHEBI:64356;

Codes from synonyms : CDR0000559066; CDR0000537233;

Origin ID

C64625;

UMLS CUI

C0657912;

CISMeF manual mappings
- Pregabalin [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pregabalin [MeSH Descriptor]
- Pregabalin [LOINC component]
- Pregabalin (substance) [SNOMED CT concept]
- Product containing pregabalin (medicinal product) [SNOMED CT concept]
- pregabalin [ATC Code]
- pregabalin [Substance BNPC]
- pregabalin [MeSH concept]
Validated automatic mappings to BTNT
- pregabalin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

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