" /> Sapacitabine - CISMeF





Preferred Label : Sapacitabine;

NCIt synonyms : N-(1-(2-Cyano-2-deoxy-beta-D-arabinofuranosyl)-2-oxo-1,2-dihydropyrimidin-4-yl)-hexadecanamide;

NCIt definition : An orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into the active triphosphate form. As an analogue of deoxycytidine triphosphate, CNDAC triphosphate incorporates into DNA strands during replication, resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue. The unmetabolized prodrug may exhibit antineoplastic activity as well.;

UNII : W335P73C3L;

InChIKey : LBGFKUUHOPIEMA-PEARBKPGSA-N;

CAS number : 151823-14-2;

Molecule name : CS-682; CYC682; CS 682;

Chemical formula : C26H42N4O5;

Codes from synonyms : 458;

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30/05/2025


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