Asparaginase Erwinia chrysanthemi

Preferred Label : Asparaginase Erwinia chrysanthemi;

NCIt synonyms : Asparaginase-Erwinia; Crisantaspasum; Crisantaspase; RC-P JZP-458; Recombinant Erwinia asparaginase JZP-458; Asparaginase Erwinia chrysanthemi (Recombinant)-rywn; Recombinant Crisantaspase JZP-458; Recombinant Asparaginase erwinia chrysanthemi JZP-458; Crisantaspase Biobetter JZP-458; Asparaginase Erwinia chrysanthemi, Recombinant-rywn;

NCIt related terms : Rylaze; Asparaginase erwinia chrysanthemi-rywn;

NCIt definition : A recombinant form of asparaginase derived from the bacterium Erwinia chrysanthemi, genetically engineered to be produced in Pseudomonas fluorescens, with potential antineoplastic activity. Upon administration, asparaginase Erwinia chrysanthemi hydrolyzes L-asparagine to L-aspartic acid and ammonia. This depletes cancer cells of asparagine, which blocks protein synthesis and tumor cell proliferation. Asparagine is critical to protein synthesis in cancer cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase Erwinia chrysanthemi can be used as an alternative in patients who are hypersensitive to Escherichia (E.) coli-derived asparaginase products.;

UNII : D733ET3F9O;

CAS number : 9015-68-3;

Drug name : Erwinase; Erwinaze; Rylaze; Enrylaze;

Molecule name : JZP-458; JZP 458; PF743;

NSC code : 106977;

Codes from synonyms : 27223; 46;

Details

Origin ID

C64260;

UMLS CUI

C3255208;

See also inter- (CISMeF)
- Product containing crisantaspase (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Crisantaspase (substance) [SNOMED CT concept]
- Product containing crisantaspase (medicinal product) [SNOMED CT concept]
- asparaginase erwinia chrysanthemi recombinant [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Asparagine [NCIt concept]
is_component_of_chemotherapy_regimen
- Asparaginase Erwinia chrysanthemi Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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