N-Desmethyltamoxifen

Preferred Label : N-Desmethyltamoxifen;

NCIt synonyms : Desmethyltamoxifen; cis-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine; 2-[4-[(1Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N-methylethanamine;

NCIt definition : A main metabolite of the selective estrogen receptor modulator tamoxifen with anti-estrogen activity. N-desmethyltamoxifen blocks estrogen from binding to the estrogen receptor. This may inhibit estrogen-associated signaling and tumor growth in estrogen-positive tumor cells. Conversion of N-desmethyltamoxifen from tamoxifen is catalyzed by cytochrome P-450 enzymes 3A4 and 3A5. N-desmethyltamoxifen is further hydroxylated, mainly by CYP2D6, to endoxifen, the major clinically active metabolite of tamoxifen.;

UNII : OOJ759O35C;

CAS number : 31750-48-8;

Molecule name : ICI 55,548;

Codes from synonyms : 30254;

Details

Origin ID

C64189;

UMLS CUI

C0067934;

Currated CISMeF NLP mapping
- N-desmethyltamoxifen [MeSH concept]
- N-desmethyltamoxifen [MeSH Supplementary Concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- N-desmethyltamoxifen [MeSH concept]
- N-desmethyltamoxifen [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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