S-Adenosylmethionine

Preferred Label : S-Adenosylmethionine;

NCIt synonyms : Active Methionine; S-Adenosyl-methionine; S-Adenosyl-l-methionine 1,4-Butanedisulfonate; 5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Hydroxide, Inner Salt;

NCIt related terms : S-Adenosyl-l-methionine;

NCIt definition : A nutritional supplement that is synthesized from adenosine triphosphate (ATP) and the amino acid methionine by the endogenous essential enzyme methionine adenosyltransferase (MAT), with potential antineoplastic activity. Upon administration, S-adenosylmethionine acts as a methyl donor for various transmethylation reactions. In cancer cells, this agent induces the methylation of tumor promoting genes, reverses DNA hypomethylation, and leads to the suppression of oncogene transcription. This induces apoptosis in and inhibits proliferation of susceptible tumor cells.;

CAS number : 29908-03-0;

Chemical formula : C15H22N6O5S;

ChEBI ID : CHEBI:15414;

Codes from synonyms : 01624;

Details

Origin ID

C63661;

UMLS CUI

C0036002;

Automatic exact mappings (from CISMeF team)
- S-adenosylmethionine [LOINC component]
- adenosyl-methionine 1,4-butanedisulfonate [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- (3s)-5'-[(3-amino-3-carboxylatopropyl)methylsulphonio]-5'-deoxyadenosine [Substance BNPC]
- S-Adenosylmethionine [MeSH Descriptor]
- S-Adenosylmethionine [MeSH concept]
- S-adenosyl-L-methionine 1,4-butanedisulfonate [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- (3s)-5'-[(3-amino-3-carboxylatopropyl)methylsulphonio]-5'-deoxyadenosine [Substance BNPC]
- Ademetionine (substance) [SNOMED CT concept]
- Product containing ademetionine (medicinal product) [SNOMED CT concept]
- S-Adenosylmethionine [MeSH Descriptor]
- S-Adenosylmethionine [MeSH concept]
- S-adenosylmethionine [LOINC component]
- ademetionine [ATC Code]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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