" /> Labetalol Hydrochloride - CISMeF





Preferred Label : Labetalol Hydrochloride;

NCIt definition : The hydrochloride form of labetalol, a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects.;

UNII : 1GEV3BAW9J;

InChIKey : WQVZLXWQESQGIF-UHFFFAOYSA-N;

CAS number : 32780-64-6;

Drug name : Trandate; Normodyne;

Chemical formula : C19H24N2O3.HCl;

NSC code : 290312;

Codes from synonyms : 30258;

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09/05/2025


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