" /> Labetalol - CISMeF





Preferred Label : Labetalol;

NCIt definition : A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects.;

UNII : R5H8897N95;

InChIKey : SGUAFYQXFOLMHL-UHFFFAOYSA-N;

CAS number : 36894-69-6;

Chemical formula : C19H24N2O3;

ChEBI ID : CHEBI:6343;

Codes from synonyms : 30283;

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20/06/2025


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