Medroxyprogesterone

Preferred Label : Medroxyprogesterone;

NCIt synonyms : 6Alpha-methyl-17alpha-hydroxyprogesterone; 6Alpha-methyl-4-pregnen-17alpha-ol-3,20-dione; (6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione; 17Alpha-hydroxy-6alpha-methylprogesterone;

NCIt related terms : Curretab; Medroxyprogesterone acetate;

NCIt definition : A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. (NCI04);

Alternative definition : NCI-GLOSS: A hormonal anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called progestins.;

UNII : HSU1C9YRES;

InChIKey : FRQMUZJSZHZSGN-HBNHAYAOSA-N;

CAS number : 520-85-4;

Drug name : Curretab;

Chemical formula : C22H32O3;

NSC code : 27408;

ChEBI ID : CHEBI:6715;

Codes from synonyms : NSC0027408; CDR0000045265; 323;

Details

Origin ID

C629;

UMLS CUI

C0025147;

Automatic exact mappings (from CISMeF team)
- Product containing medroxyprogesterone (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Hormone [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Medroxyprogesterone (substance) [SNOMED CT concept]
- Product containing medroxyprogesterone (medicinal product) [SNOMED CT concept]
- medroxyprogesterone [ATC Code]
- medroxyprogesterone [ATC Code]
- medroxyprogesterone [ATC Code]
- medroxyprogesterone [Substance BNPC]
- medroxyprogesterone [MeSH Descriptor]
- medroxyprogesterone [MeSH concept]
- medroxyprogesterone preparation [SNOMED Notion]
Validated automatic mappings to BTNT
- medroxyprogesterone [ATC Code]
- medroxyprogesterone [ATC Code]
- medroxyprogesterone [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Progesterone Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Aminoglutethimide/Danazol/Medroxyprogesterone/Tamoxifen [NCIt concept]
- Conjugated Estrogens/Medroxyprogesterone [NCIt concept]
- Cyclophosphamide/Doxorubicin/Etoposide/Medroxyprogesterone/Quinine [NCIt concept]
- Medroxyprogesterone/Mitomycin/Vinblastine [NCIt concept]
- Medroxyprogesterone/Tamoxifen [NCIt concept]

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