Tasisulam - CISMeF

Preferred Label : Tasisulam;

NCIt synonyms : N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide;

NCIt definition : An acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity.;

UNII : 1YC4W9MSLJ;

InChIKey : WWONFUQGBVOKOF-UHFFFAOYSA-N;

CAS number : 519055-62-0;

Molecule name : LY-573636;

Chemical formula : C11H6BrCl2NO3S2;

Details

Origin ID

C62794;

UMLS CUI

C2363400;

Automatic exact mappings (from CISMeF team)
- N-((5-bromo-2-thienyl)sulfonyl)-2,4-dichlorobenzamide [MeSH Supplementary Concept]
- tasisulam [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tasisulam [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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