" /> 5-Fluoro-2-Deoxycytidine - CISMeF





Preferred Label : 5-Fluoro-2-Deoxycytidine;

NCIt synonyms : FdCyd; Cytidine, 2'-deoxy-5-fluoro-; 5-Fluoro-2-Deoxycytidine;

NCIt related terms : 5-FLUORO-2'-DEOXYCYTIDINE;

NCIt definition : An antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is converted by intracellular deaminases to the cytotoxic agent 5-Fluorouracil (5-FU). 5-FU is subsequently metabolized to active metabolites including 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP binds to and inhibits thymidylate synthase, thereby reducing the production of thymidine monophosphate, which leads to depletion of thymidine triphosphate. This inhibits DNA synthesis and cell division. FUTP competes with uridine triphosphate for incorporation into the RNA strand thus leading to an inhibition of RNA and protein synthesis. Other fluorouracil metabolites also get incorporated into both DNA and RNA, thereby further hampering cellular growth.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. It may prevent the growth of tumors by stopping cancer cells from dividing and by killing them. It is a type of antimetabolite.;

UNII : KUA4693H5W;

InChIKey : IDYKCXHJJGMAEV-RRKCRQDMSA-N;

CAS number : 10356-76-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 10356-76-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : Ro 5-1090;

Chemical formula : C9H12FN3O4;

NSC code : 48006;

Codes from synonyms : CDR0000546729; CDR0000528024;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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