Preferred Label : Obatoclax Mesylate;
NCIt synonyms : 2-(2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-3-methoxy-2H-pyrrol-5-yl)-1H-indole
Monomethanesulfonate;
NCIt definition : The mesylate salt of obatoclax, a synthetic small-molecule inhibitor of the bcl-2
family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax
binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic
proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation
of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins
(bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers,
including those of the lymphatic system, breast, lung, prostate, and colon.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of several types of cancer.
It is a form of obatoclax, which blocks the activity of certain proteins needed for
cells to live and may cause tumor cells to die. It is a type of apoptosis inducer.;
UNII : 39200FJ43J;
InChIKey : ZFKXDVMHNXPEIY-PEZBNFGJSA-N;
CAS number : 803712-79-0;
Molecule name : GX15-070MS;
Chemical formula : C20H19N3O.CH4O3S;
Codes from synonyms : CDR0000597162;
Origin ID : C62771;
UMLS CUI : C1831948;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
