Radium Ra 223 Dichloride

Preferred Label : Radium Ra 223 Dichloride;

NCIt synonyms : Alpharadin; Radium-223; Radium 223 Dichloride; Radium-223 Dichloride; Radium-223 Chloride;

NCIt related terms : RADIUM RA-223 DICHLORIDE;

NCIt definition : A radiopharmaceutical composed of the dichloride salt of the alpha-emitting isotope radium Ra 223, with antineoplastic activity. Like calcium, radium targets bone tissue and preferentially accumulates in osteoblastic lesions, such as those seen in areas of bone metastases. Radium Ra 223 forms complexes with hydroxyapatite and becomes incorporated into the bone matrix. The radioisotope Ra 223 kills bone cancer cells through local emission of high energy alpha particles, causing DNA double-strand breaks and tumor regression in the skeleton. The short range effects of alpha emission allows for localized DNA damage with limited toxicity to nearby healthy bone tissue.;

UNII : RJ00KV3VTG;

InChIKey : RWRDJVNMSZYMDV-SIUYXFDKSA-L;

CAS number : 444811-40-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 444811-40-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Xofigo;

Molecule name : BAY 88-8223; BAY88-8223;

Chemical formula : 2Cl.Ra;

Details

Origin ID

C62535;

UMLS CUI

C3541342;

Automatic exact mappings (from CISMeF team)
- Radium-223 [MeSH concept]
Currated CISMeF NLP mapping
- 223 radium [SNOMED Notion]
- Radium (223-Ra) dichloride (substance) [SNOMED CT concept]
- Radium-223 [MeSH Supplementary Concept]
- Radium-223 (substance) [SNOMED CT concept]
- radium (223Ra) dichloride [ATC Code]
- radium ra 223 dichloride [MeSH Supplementary Concept]
- radium ra 223 dichloride [MeSH concept]
Semantic type(s)
- Inorganic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Radium (223-Ra) dichloride (substance) [SNOMED CT concept]
- radium ra 223 dichloride [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Radium Ra 223 [NCIt concept]
is_salt_form_of
- Radium Ra 223 [NCIt concept]

Keyword's position in hierarchy(ies) :

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