Radium Ra 223 - CISMeF

Preferred Label : Radium Ra 223;

NCIt synonyms : Ra-223;

NCIt related terms : RADIUM RA-223; Radium-223;

NCIt definition : An alpha-emitting isotope, with antineoplastic activity. Upon administration, radium Ra 223, like calcium, targets bone tissue and preferentially accumulates in osteoblastic lesions, such as those seen in areas of bone metastases, where it forms complexes with hydroxyapatite and becomes incorporated into the bone matrix. The radioisotope Ra 223 kills bone cancer cells through local emission of high energy alpha particles, causing DNA double-strand breaks and tumor regression in the skeleton. The short range effects of alpha emission allows for localized DNA damage with limited toxicity to nearby healthy bone tissue.;

UNII : 8BR2SOL3L1;

CAS number : 15623-45-7;

NCI Metathesaurus CUI : CL1915365;

Codes from synonyms : 428;

Details

Origin ID

C200686;

UMLS CUI

C0303282;

Semantic type(s)
- Element, Ion, or Isotope [UMLS semantic type]
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
UMLS correspondences (same concept)
- 223 radium [SNOMED Notion]
- Product containing radium-223 (medicinal product) [SNOMED CT concept]
- Ra-223 [LOINC Challenge]
- Radium-223 [MeSH Supplementary Concept]
- Radium-223 (substance) [SNOMED CT concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Radium Ra 223 Dichloride [NCIt concept]
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- Radium Ra 223 Dichloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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